Summary:
Scientists claim they have cured advanced skin cancer for the first time using the patient's own cells cloned outside the body. A 52-year-old man involved was free of melanoma two years after treatment which consisted of selecting a number of cancer-fighting immune cells, making five billion copies, and putting them back in the body. Two months later, scans showed the tumours had disappeared. The researchers focused on melanoma because the disease was well understood compared with other cancers, but other cancers could potentially be targeted. (Published: 19/06/08)
Notes:
- Scientists at the Fred Hutchinson Cancer Research Center in Seattle, led by Dr Cassian Yee
- selected CD4+ T immune cells from a sample of the man's white blood cells which had been specifically primed to attack a chemical found on the surface of melanoma cells
- were multiplied in the laboratory, and put back in their billions to see if they could mount an effective attack on the tumours
- two months later, scans showed the tumours had disappeared
- after two years, the man remained disease-free
- The new cells persisted in the body for months after the treatment.
- Authors point out that their technique applied only to a patient with a particular type of immune system and tumour type, and could work for only a small percentage of people with advanced skin cancer.
- Karol Sikora, a cancer expert at Imperial College in London:
- described the research as "pretty exciting" with potentially wide application
- said the researchers had focused on melanoma because the disease was well understood compared with other cancers, but other cancers could potentially be targeted
- "I think we will be able to harness the power of the immune system. Eventually we will learn how to control cancer, in other words we will suppress it. Patients will live with their cancer, and die with their cancer, but not of their cancer - it will be like diabetes today."
- spokesman for Cancer Research UK:
- said more research would be needed, adding: "This is another interesting demonstration of the huge power of the immune system to fight some types of cancer. Although the technique is complex and difficult to use for all but a few patients, the principle that someone's own immune cells can be expanded and made to work in this way is very encouraging for the work that ourselves and others are carrying out in this field."
